Structure, properties, spectra, suppliers and links for. A wide variety of price itaconic acid options are available to you, such as grade standard. Synthesis and application of sodium octylphenol polyoxyethylene 10 itaconate monoester. Succinic acid was found to decrease the surface tension of water already at very low concentrations. Based on the preliminary test, three saturated samples in water are prepared, tightly stoppered and agitated at 30after one day, one of the samples was equilibrated for 24hours at 20. Aspergillus terreus nrrl 1960 was grown on porous disks rotating intermittently in and out of the liquid phase. It is a dicarboxylic acid and an olefinic compound. About 68% of these are organic acid, 3% are inorganic acids, and 0% are dyestuff intermediates. The information provided in this safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication. Biological routes to itaconic and succinic acids in. Polymerization of itaconic acid summary polyitaconic acid pia has been prepared by various methods namely in radical polymerization in the presence of various initiators and.
For increasing the productivity, the influence of starting substrate concentration, the optimum timing of. Asia pacific dominated the global itaconic acid market both in terms of volume and revenue in 2014. Synthesis and characterization of sodium noctyl sulfoitaconate diester anionic surfactant article pdf available in journal of surfactants and detergents 192. Surface free energy components by polardispersion and.
A simple preliminary test is carried out, and the approximate solubility in water is 10050 gl. Ep1018533a2 siliconecontaining low surface tension film. The resin and film have good release from adhesives and good processability. A mixture of itaconic acid, 1butanol2isooctanol and catalyst were put into a 100 ml threeneck flask equipped with a reflex condenser under continuous stirring. Itaconic acid is used to enhance bioactivities when it undergoes polymerization and can be used in tissue engineering.
Main physicochemical properties of synthesized surfactants have been measured and. In this paper, we present the synthesis of a new family of surfactants having c12 and c18 alkyl chains obtained from itaconic acid and fatty amines, molecules industrially obtained from renewable resources. Decrease surface tension progressively, as with most. However, the production cost of itaconic acid is too high to be economically competitive with the petrochemicalbased products. Ia polyol, intrinsic viscosity iv, tensile strength, elongation, shored. Historically, itaconic acid was obtained by the distillation of citric acid, but currently it is produced by fermentation. Itaconic acid is a naturally occurring bioactive monomer and is also derived from citric acid. This dicarboxylic acid is a white solid that is soluble in water, ethanol, and acetone. List of surface tensions and surface energies dataphysics. Synthesis, characterization and in vitro anticancer. Optimization of itaconic acid production by aspergillus. A series of novel itaconic acid based asymmetrical gemini surfactants containing two long alkyl chains.
China itaconic acid market size is projected to surpass usd 20 million valuation by 2024. The pyrrole alkyalkone derivative which compounded by itaconic acid and aromatic diamine is good additive of lubricating agent,detergent,medicines or weed killer. The resin and film are formed from i polyolefin, ii specific polysiloxanes in two separate groupings, iii vinyl silane compounds, and optionally an organic peroxide grafting agent and an organometallic moisture curing agent. Syntheses, surface activities and aggregation morphologies. Itaconic acid and its polymers can be made into effective deodorant by adding a little natural substance, they can react with alkaline or acidic. The animals received a single oral dose of 1500 mgkg. We extend our previous study of surface tension of ionic solutions and apply it to the case of acids and salts with strong ionsurface. Sigmaaldrich offers a number of itaconic acid products. A wide variety of itaconic acid options are available to you, such. Nonionic surfactants based on copolymers of dioctyl. Improving itaconic acid production through genetic engineering of an industrial aspergillus terreus strain. A series of novel itaconic acid based asymmetrical gemini surfactants containing two long alkyl chains, two selfsame nonionic groups along with an anionic moieties covalently attached by an itaconic acid spacer group polyoxyethylene laurinol ether sodium sulfoitaconate.
Itaconic acid is an unsaturated dicarboxylic acid with two pka values at 3. Plssn have been synthesized through esterification and sulfonation reaction using itaconic anhydride ian and. Itaconic acid, or methylidenesuccinic acid, is an organic compound. To this end, a carbon and energy balance for itaconic acid formation was established, which is 0. In combination with acrylamide to form polyacrylamidecoitaconicacid to synthesize biodegradable superabsorbent polymers.
As a comonomer in the polymerization of polyacrylonitrile pan to promote the thermooxidative stabilization of polymer. Itaconic acid can react with acrylic and methacrylic acid or their esters to prepare resins which can be widely used in emulsion coating, leather coating, coatings for car, refrigerator and other electrical appliances to improve adhesion, color and weather resistance. Itaconic acid is a dicarboxylic acid that is methacrylic acid in which one of the methyl hydrogens is substituted by a carboxylic acid group. Direct production of itaconic acid from liquefied corn. Synthesis and characterization of sodium n octyl sulfoitaconate diester anionic surfactant article pdf available in journal of surfactants and detergents 192. A siliconecontaining resin, film and film on a subweb are described. Ternary solution of sodium chloride, succinic acid and water. Itaconic acid is used as a biobased, renewable building block in the polymer industry. Continuous production of itaconic acid by aspergillus. The name itaconic acid was devised as an anagram of aconitic acid, another derivative of citric acid. Definition a dicarboxylic acid that is methacrylic acid in which one of the methyl hydrogens is substituted by a carboxylic acid group. This table is provided as an information service by diversified enterprises.
The surprising role of an industrial compound as a mammalian antimicrobial metabolite thekla cordes,1,2. Enhanced itaconic acid production in aspergillus niger. This table highlights polardispersion and acidbase breakouts of surface free energy, as well as hansen solubility parameters and radius of interaction, for a variety of polymers. Itaconic acid and its esters are good additive of making synthetic fibre,plastics and surface active agent. Based on guideline eec 84449 b12, a micronucleus test was performed to assess the ability of itaconic acid to induce clastogenicity in mice bone morrow cells. Citric acid production by aspergillus niger and itaconic acid production by aspergillus terreus are two major examples of technical scale fungal fermentations based on metabolic overflow of primary metabolism.
The effect of temperature, ph, disk rotation speed, and feed rate on the itaconic acid concentration and volumetric productivity were studied. Wilson, and floyd deeds from the pharmacology laboratory, bureau of agricultural and industrial chemistry, agricultural research administration, united states department of agriculture, albany, california received for publication, september 24, 1951. Surface tensions plotted as a function of the concentration of plssn at different temperature. Itaconic acid is on the doe department of energy top 12 list of biotechnologically produced building block chemicals and is produced commercially by aspergillus terreus. Itaconic acid is generally produced from raw corn starch, including three steps. These materials might also improve the bioavailability of the therapeutic agent by 1 only releasing it at the site of absorption in the intestine once the ph in the gastrointestinal tract has increased above the pka of itaconic acid ia and the network has swollen, and 2 by increasing its residence time in the intestine through bioadhesive. The copolymers were obtained by reprecipitation from petroleum ether 40. It held a share of more than 50% of the global itaconic acid market in 2014. The effects of reaction temperature, reaction time, molar ratios of noctanol to ia and the catalyst dosage on the esterification were investigated. Itaconic acid is a white colourless crystalline carboxylic acid obtained by the fermentation of carbohydrates and used in the manufacture of synthetic resins.
Itaconic acid market size, share, price report 2024. Various parameters, such as the molar ratio of 1butanol2isooctanol to itaconic acid, amount of catalyst and reaction time were varied to optimize the reaction conditions. Exploring saccharomyces cerevisiae to improve microbebased production of itaconic acid. Stars this entity has been manually annotated by the chebi team. Syntheses, surface activities and aggregation morphologies of a. The surface tension and the critical micelle concentration. Exploring saccharomyces cerevisiae to improve microbe. Characterization of phresponsive hydrogels of poly. Surfactants are a wide class of compounds used in a broad spectrum of industrial and everyday applications. Succinic acid and itaconic acid are two platform chemicals with very similar molecular structures, distinguished.
Four series of nonionic copolymer surfactants have been prepared by the free radical copolymerizations of dioctyl itaconate doi with dioxypropylated itaconic acid. Manganese deficiency is required for high itaconic acid. Surface tensions and densities of oxalic, malonic, succinic, maleic. Itaconic acid also called methylene succinic acid is a white crystalline carboxylic acid obtained by the fermentation of carbohydrates. Itaconic acid, itaconic acid supplier, itaconic acid distributor, cas 97654, itaconic acid manufacturer, itaconic acid wholesale. Unsaturated solid bond makes a conjugated system with carbonly group. All the acids lower the surface tension of pure water. It is concluded that itaconic acid did not show any clastogenic activity in cho cells under our experimental conditions. The structure features of these surfactants have been confirmed by ir and 1 h nmr spectra. High concentration of production capacities due to the shutdown of the manufacturing plants of itaconic acid in other parts of the world has led to this growth.
Improving itaconic acid production through genetic engineering of an. Itaconic acid is a potential green chemical to substitute maleic anhydride in upr production owing to its similar structure and has potential to be a good substitute. Get a quick quote download product spec download sds. Surface tension values of some common test liquids for surface energy analysis. A series of novel itaconic acid based asymmetrical gemini surfactants. With all the above facts in mind, we have to synthesize an aliphatic. These surfactants exhibit excellent properties of self. Production of itaconic acid from optimization of itaconic acid production by aspergillus terreus suk1 using responce surface 223 metabolic modelling of itaconic acid fermentation with ustilago maydis.
Aspergillus niger was selected as a host for producing itaconic acid due to its versatile and tolerant character in various growth environments, and its extremely high capacity of accumulating the precursor of itaconic acid. Itaconic acid is used as a biobased, renewable building block in the. Expressing the cad gene from aspergillus terreus opened the metabolic pathway towards itaconic acid in a. Both organic acids are formed by the same metabolic pathway, but whereas citric acid is the end product in a. Process engineering of ph tolerant ustilago cynodontis for efficient. Surface tension is the tendency of liquid surfaces to shrink into the minimum surface area. Synthesis and characterization of sodium noctyl sulfoitaconate. The plssn species have lower equilibrium surface tension. The surface tension c and the critical micelle concentration cmc were determined as 25. This immobilized fungal cell bioreactor was used to produce itaconic acid from glucose in a continuous operation. It can be obtained directly from fermentation of glucose. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification.